American Association for Cancer Research® (AACR) Annual Meeting 2024

Article collection

We are proud to present a special collection of articles for the American Association for Cancer Research^® (AACR) Annual Meeting 2024. This curated selection showcases the cutting-edge advancements and novel perspectives published in journals from Elsevier's Oncology Journal Network. We invite you to explore this collection and delve deeper into the exciting advancements shaping the future of cancer research.

Annals of Oncology

• Circulating tumor DNA and radiological tumor volume identify patients at risk for relapse with resected, early-stage non-small-cell lung cancer opens in new tab/window

Blood Neoplasia

• Comparison of TP53 Mutations in Myelodysplasia and Acute Leukemia Suggests Divergent Roles in Initiation and Progression opens in new tab/window

Cancer Epidemiology

• Latin America and the Caribbean Code Against Cancer 1st Edition: A landmark for cancer prevention in the region opens in new tab/window

• Association of the affordable care act with perceived health care quality of cancer survivors opens in new tab/window

Cancer Letters

• Editorial: The progress and challenges of hematological malignancies in the era of big data and new therapy opens in new tab/window

• Immune-checkpoint inhibitor resistance in cancer treatment: Current progress and future directions opens in new tab/window

• The past, present, and future of liver cancer research in China opens in new tab/window

• Ferroptosis: Promising approach for cancer and cancer immunotherapy opens in new tab/window

• Tackling the current dilemma of immunotherapy in extensive-stage small cell lung cancer: A promising strategy of combining with radiotherapy opens in new tab/window

• Oncolytic adenovirus as pancreatic cancer-targeted therapy: Where do we go from here? opens in new tab/window

• Novel strategies optimize immunotherapy by improving the cytotoxic function of T cells for pancreatic cancer treatment opens in new tab/window

• PROTACs: Novel tools for improving immunotherapy in cancer opens in new tab/window

Cancer Pathogenesis and Therapy

• Role of T cells in cancer immunotherapy: Opportunities and challenges opens in new tab/window

• PI3K/AKT/mTOR pathway, hypoxia, and glucose metabolism: Potential targets to overcome radioresistance in small cell lung cancer opens in new tab/window

• Clinical characteristics and treatment outcomes of Chinese diffuse large B-cell lymphoma patients in the era of rituximab (2005–2018) opens in new tab/window

Cancer Treatment and Research Communications

• Antibody-drug conjugates, immune-checkpoint inhibitors, and their combination in advanced non-small cell lung cancer opens in new tab/window

Cancer Treatment Reviews

• Histology independent drug development – Is this the future for cancer drugs? opens in new tab/window

• Breaking barriers in triple negative breast cancer (TNBC) – Unleashing the power of antibody-drug conjugates (ADCs) opens in new tab/window

Chinese Medical Journal Pulmonary and Critical Care Medicine

• Role of c-Myc in lung cancer: Progress, challenges, and prospects opens in new tab/window

• Pyroptosis: A promising target for lung cancer therapy opens in new tab/window

• Changing profile of lung cancer clinical characteristics in China: Over 8-year population-based study opens in new tab/window

Clinical Breast Cancer

• Risk of Recurrence in Patients With HER2+ Early-Stage Breast Cancer: Literature Analysis of Patient and Disease Characteristics opens in new tab/window

• Efficacy and Safety of Trastuzumab Deruxtecan in Breast Cancer: A Systematic Review and Meta-Analysis opens in new tab/window

Clinical Colorectal Cancer

• Incidence of Disease Recurrence in Patients With Colon and Upper Rectum Adenocarcinoma Stage II and III Receiving Adjuvant Capecitabine Monotherapy: Do Number of Chemotherapy Cycles and Relative Dose Intensity of the Drug Play a Role? opens in new tab/window

• Systemic Therapy for Patients With Pancreatic Cancer: Current Approaches and Opportunities for Novel Avenues Toward Precision Medicine opens in new tab/window

Clinical Genitourinary Cancer

• The Impact of Blue Light Cystoscopy Use Among Nonmuscle Invasive Bladder Cancer Patients in an Equal Access Setting: Implications on Recurrence and Time to Recurrence opens in new tab/window

• A Phase I Study of Capivasertib in Combination With Abiraterone Acetate in Patients With Metastatic Castration-Resistant Prostate Cancer opens in new tab/window

Clinical Imaging

• A comprehensive survey of deep learning research on medical image analysis with focus on transfer learning opens in new tab/window

• Decoding radiology reports: Potential application of OpenAI ChatGPT to enhance patient understanding of diagnostic reports opens in new tab/window

• CT radiomics for differentiating oncocytoma from renal cell carcinomas: Systematic review and meta-analysis opens in new tab/window

Clinical Lung Cancer

• Amivantamab, an Epidermal Growth Factor Receptor (EGFR) and Mesenchymal-epithelial Transition Factor (MET) Bispecific Antibody, Designed to Enable Multiple Mechanisms of Action and Broad Clinical Applications opens in new tab/window

• A Multicenter Retrospective Chart Review of Clinical Outcomes Among Patients With KRAS G12C Mutant Non–Small Cell Lung Cancer opens in new tab/window

Clinical Lymphoma Myeloma and Leukemia

• Progression-Free Survival of Daratumumab Versus Bortezomib Triplet Combination With Lenalidomide and Dexamethasone in Transplant Ineligible Patients With Newly Diagnosed Multiple Myeloma: TAURUS Chart Review Study opens in new tab/window

• Recommendations for Management of Secondary Antibody Deficiency in Multiple Myeloma opens in new tab/window

Clinical Surgical Oncology

• Impact of diverting stoma on long-term survival in patients with rectal cancer: A nationwide study based on health insurance claims data opens in new tab/window

• Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (V. 2023) opens in new tab/window

Clinics

• Could be FOXO3a, miR-96-5p and miR-182-5p useful for Brazilian women with luminal A and triple negative breast cancers prognosis and target therapy? opens in new tab/window

• Programmed cell death-1 and its ligands: Current knowledge and possibilities in immunotherapy opens in new tab/window

Critical Reviews in Oncology/Hematology

• Characteristics of gastric cancer around the world opens in new tab/window

• Ferroptosis induction via targeting metabolic alterations in head and neck cancer opens in new tab/window

Current Problems in Cancer

• Folate Receptor as a Biomarker and Therapeutic Target in Solid Tumors opens in new tab/window

• Tisotumab vedotin in recurrent or metastatic cervical cancer opens in new tab/window

• Comparative effect of progressive relaxation technique and Benson's technique on anxiety and fatigue in cancer survivors - an experimental study opens in new tab/window

EJC: Paediatric Oncology

• The impact of infertility and physical late effects on psycho-social well-being of long-term childhood cancer survivors: A cross-sectional study opens in new tab/window

• Olfactory neuroblastoma in children and adolescents: The EXPeRT recommendations for diagnosis and management opens in new tab/window

EJC Skin Cancer

• Quality of life issues faced by patients with keratinocyte cancer: A systematic review opens in new tab/window

• Spontaneous haematoma: A unique immune-related adverse event alongside other cutaneous reactions in a patient treated with pembrolizumab for metastatic melanoma opens in new tab/window

• Merkel cell carcinoma with leptomeningeal involvement: A complex case report opens in new tab/window

ESMO Gastrointestinal Oncology

• Unleashing the power of anti-HER2 therapies in metastatic colorectal cancer: paving the way for a brighter future opens in new tab/window

ESMO Open

• Artificial intelligence for detection of microsatellite instability in colorectal cancer—a multicentric analysis of a pre-screening tool for clinical application opens in new tab/window

• Effectiveness of next-generation sequencing for patients with advanced non-small-cell lung cancer: a population-based registry study opens in new tab/window

ESMO Real World Data and Digital Oncology

• Relationship of tumor fraction in circulating tumor DNA with prognosis in patients with advanced urothelial cancer opens in new tab/window

European Journal of Cancer

• Recent advances and future strategies in first-line treatment of ES-SCLC opens in new tab/window

• Cross-trial comparisons for the adjuvant treatment of MSI colorectal cancer: dare to dream the future scenarios. opens in new tab/window

• Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives opens in new tab/window

• A new prognostic model in chemotherapy-treated patients with recurrent or metastatic head and neck cancer: An analysis of ECOG-ACRIN E1305 opens in new tab/window

Gynecologic Oncology

• Inclusion, diversity, equity, and access (IDEA) in gynecologic cancer clinical trials: A joint statement from GOG foundation and Society of Gynecologic Oncology (SGO) opens in new tab/window

• Enhanced recovery after surgery (ERAS®) society guidelines for gynecologic oncology: Addressing implementation challenges - 2023 update opens in new tab/window

• Financial toxicity: A practical review for gynecologic oncology teams to understand and address patient-level financial burdens opens in new tab/window

• Lunchbox trial: A randomized phase III trial of cisplatin and irradiation followed by carboplatin and paclitaxel versus sandwich therapy of carboplatin and paclitaxel followed by irradiation then carboplatin and paclitaxel for advanced endometrial carcinoma opens in new tab/window

Gynecologic Oncology Reports

• Strategies for prevention and management of ocular events occurring with mirvetuximab soravtansine opens in new tab/window

• Digital cervicography for cervical cancer screening in low-resource settings: A scoping review opens in new tab/window

• Activity of pembrolizumab and lenvatinib in mismatch repair deficient (dMMR) endometrial cancer patients who have failed pembrolizumab monotherapy: A case series opens in new tab/window

Hematology, Transfusion and Cell Therapy

• CAR-T cell therapy for multiple myeloma: a practical toolkit for treatment in Brazil opens in new tab/window

Immuno-Oncology and Technology

• CD47–SIRPα-targeted therapeutics: status and prospects opens in new tab/window

• Quantitative RNA assessment and long-term stability in the FFPE tumor samples using Digital Spatial Profiler opens in new tab/window

• Basics of advanced therapy medicinal product development in academic pharma and the role of a GMP simulation unit opens in new tab/window

Journal of Bone Oncology

• Management of bone metastasis and cancer treatment-induced bone loss during the COVID-19 pandemic: An international perspective and recommendations opens in new tab/window

• Optimization of a syngeneic murine model of bone metastasis opens in new tab/window

Journal of Cancer Policy

• Cross-cultural adaptation of the PROFFIT Instrument to measure financial toxicity in people living with cancer within a UK population opens in new tab/window

• Effect of a same day appointment initiative on racial disparities in access for radiation oncology opens in new tab/window

Journal of Geriatric Oncology

• Predicting future cancer incidence by age, race, ethnicity, and sex opens in new tab/window

• Impact of pharmaceutical care interventions on multidisciplinary care of older patients with cancer: A systematic review opens in new tab/window

• A scoping review of ageism towards older adults in cancer care opens in new tab/window

Journal of Liquid Biopsy

• Liquid biopsy in detecting early non-small cell lung cancer opens in new tab/window

• Real-time assessment of HER2 status in circulating tumor cells of breast cancer patients: Methods of detection and clinical implications opens in new tab/window

Journal of the National Cancer Center

• Cancer incidence and mortality in China, 2022 opens in new tab/window

• Chinese quality control indices for standardized diagnosis and treatment of renal cancer (2022 edition) opens in new tab/window

• The breast cancer tumor microenvironment and precision medicine: immunogenicity and conditions favoring response to immunotherapy opens in new tab/window

Leukemia Research

• From bone marrow failure syndromes to VEXAS: Disentangling clonal hematopoiesis, immune system, and molecular drivers opens in new tab/window

• Evaluation of the Simplified Score to Predict Early Relapse in Multiple Myeloma (S-ERMM) in the MMRF CoMMpass study opens in new tab/window

Leukemia Research Reports

• Real world experience with ropeginterferon alpha-2b (Besremi) in essential thrombocythaemia and polycythaemia vera following exposure to pegylated interferon alfa-2a (Pegasys) opens in new tab/window

• Allogeneic stem cell transplant for multiple myeloma & myelofibrosis with split-dose busulfan, fludarabine & cyclophosphamide opens in new tab/window

• Location, location, location: A mini-review of CEBPA variants in patients with acute myeloid leukemia opens in new tab/window

Lung Cancer

• Lurbinectedin in patients with small cell lung cancer with chemotherapy-free interval ≥30 days and without central nervous metastases opens in new tab/window

Medical Dosimetry

• Clinical target volume segmentation based on gross tumor volume using deep learning for head and neck cancer treatment opens in new tab/window

• Dosimetric benefits of 3D-printed modulated electron bolus following lumpectomy and whole-breast radiotherapy for left breast cancer opens in new tab/window

• Medical dosimetry virtual clinical education: Mentors’ perspectives opens in new tab/window

Neoplasia

• UALCAN: An update to the integrated cancer data analysis platform opens in new tab/window

• Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor opens in new tab/window

• Acral melanoma: new insights into the immune and genomic landscape opens in new tab/window

• Pioneering models of pediatric brain tumors opens in new tab/window

• A sensitive and robust plasma-based DNA methylation panel for early detection of target gastrointestinal cancers opens in new tab/window

• Identification and characterization of circular RNAs as novel putative biomarkers to predict anti-PD-1 monotherapy response in metastatic melanoma patients – Knowledge from two independent international studies opens in new tab/window

• Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach opens in new tab/window

• Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer opens in new tab/window

• Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients opens in new tab/window

• Current state of pediatric neuro-oncology imaging, challenges and future directions opens in new tab/window

• Indigenous peoples and inclusion in clinical and genomic research: Understanding the history and navigating contemporary engagement opens in new tab/window

Oral Oncology

• Pembrolizumab versus methotrexate, docetaxel, or cetuximab in recurrent or metastatic head and neck squamous cell carcinoma (KEYNOTE-040): Subgroup analysis by pattern of disease recurrence opens in new tab/window

• Functional considerations between flap and non-flap reconstruction in oral tongue cancer: A systematic review opens in new tab/window

• Immunochemotherapy alone or immunochemotherapy plus subsequent locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma opens in new tab/window

Oral Oncology Reports

• Bibliometrics study of the cancer research in the faculties of medicine and dentistry during Syrian crisis opens in new tab/window

• Immune-related adverse events following checkpoint inhibitor treatment in head and neck cancers: A comprehensive review opens in new tab/window

Photodiagnosis and Photodynamic Therapy

• Whole-course care in photodynamic therapy of colorectal cancer: A short communication opens in new tab/window

Radiation Medicine and Protection

• Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and tumor tissues opens in new tab/window

• Prevention and treatment for radiation-induced skin injury during radiotherapy opens in new tab/window

• HIF-1 signaling: A key orchestrator of cancer radioresistance opens in new tab/window

Radiography

• Comparing the performance of full-field digital mammography and digital breast tomosynthesis in the post-treatment surveillance of patients with a history of breast cancer: A retrospective study opens in new tab/window

• Breast cancer patients’ experiences on their individual care pathway: A qualitative study opens in new tab/window

Surgical Oncology Insight

• Unsupervised clustering using multiple correspondence analysis reveals clinically-relevant demographic variables across multiple gastrointestinal cancers opens in new tab/window

• The prognostic role of post-operative cfDNA after resection of Colorectal Liver Metastases: A Systematic Review and Meta-Analysis opens in new tab/window

• The effect of the pandemic on colorectal cancer in the United States: An increased disease burden opens in new tab/window

The Breast

• Breast cancer highlights from 2023: Knowledge to guide practice and future research opens in new tab/window

• Best of the year: Advanced breast cancer in 2023 opens in new tab/window

Translational Oncology

• Epithelial-Mesenchymal Transition in Cancer: A Historical Overview opens in new tab/window

• 3D Bioprinted cancer models: Revolutionizing personalized cancer therapy opens in new tab/window

• MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer opens in new tab/window

• Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection opens in new tab/window

• m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis opens in new tab/window

Elsevier’s Oncology Journal Network